Alpha1 antritrypsin deficiency vs Chronic smoker Emphysema

	Alpha1-Anti-trypsin deficiency	Chronic smoker emphysema
1	Severe Pan-acinar emphysema	Centrilobular/Paraseptal emphysema
2	Basal zone dominant	Upper zone dominant
3	A/w Bronchiectasis, liver cirrhosis	Cysts with well-defined margins
4	Rare, Auto-recessive	A/w pollutant ie Smoking